chromosome breakage

If not repaired, the breakage can result in lethality or chromosome breakage, and if misrepaired, it can cause mutation, gene instability and the increased rate of tumorigenesis.

双链断裂得不到修复，细胞将会死亡或发生染色体断裂、丢失，若是错误修复将导致基因突变或基因组不稳定，增加癌症的风险度。

In this study, MMC-induced chromosome breakage tests have been done on 27 healthy controls and 51 patients with bone marrow failure 〔 including 48 patients with aplastic anemia ( AA) and 3 patients with FA before cytogenetic analysis 〕.

本研究通过对我国27例正常人和51例骨髓造血功能衰竭的患者（48例临床诊断为AA，3例临床诊断为FA）进行了丝裂霉素C（MMC）诱导的染色体断裂试验。

Thus, the NEU-induced primary chromosome breakage may not be repaired by the ligase.

由NEU所诱发的染色体初级断裂不能为连接酶所修复。

The cytokinesis-block micronucleus test ( CBMNT) is a method for measuring chromosome breakage and/ or whole chromosome loss.

胞质分裂阻滞微核法（cytokinesis-block micronucleus test，CBMNT）是一套以检测染色体断裂和染色体分离为主的实验体系。

The percentage of chromosome breakage cells had no different between test ( l0.67%) and contrast ( 8. 00%, P> 0. 05).

试验组染色体断裂细胞百分率（10.67%）与对照组（8.00%）之间差异不显著（P>0.05）；

Sodium arsenite was also shown to produce increased sister chromatid exchange in CEO cells and increased chromosome breakage in human lymphocytes.

亚砷酸钠还可引起CHO细胞的姐妹染色单体互换率的增加和人类淋巴细胞染色体的断裂和畸变。

It showed very significant difference in the rate of micronucleus and frequency of chromosome breakage between the adding medicine groups and the control group ( P < 0. 01).

本组资料表明，微核率和染色体断裂频率在各加药组和对照组之间均有非常显著差异（P＜0.01）。